The combination of the selective histone deacetylase inhibitor entinostat plus a CDK4/6 inhibitor demonstrates greater synergistic antitumor activity against estrogen receptor (ER)-positive breast cancer and triple-negative (TN) breast cancer than either agent alone.
MonarchE is an ongoing, open-label phase 3 study designed to evaluate invasive disease-free survival in patients with hormone receptor‒positive, HER2-negative advanced breast cancer receiving abemaciclib plus standard-of-care adjuvant endocrine therapy (ET).
In a retrospective cohort study of more than 17,000 patients with hormone receptor (HR)-positive, HER2-negative breast cancer, changes in the treatment paradigm have more young patients receiving ovarian suppression as part of initial therapy, and patients regardless of age receiving treatment with the CDK4/6 inhibitor palbociclib, whereas a decrease has been seen in use of tamoxifen for younger patients and overall.
In the MONALEESA-2 study, the CDK4/6 inhibitor ribociclib, in combination with letrozole, led to significant prolongation of progression-free survival while maintaining quality of life in postmenopausal women with advanced breast cancer.
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