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The role of intravenous (IV) iron as an addition to erythropoiesis-stimulating agents (ESAs) to optimize therapy in patients with anemia from cancer or chemotherapy-induced anemia has been examined in nine prospective, randomized trials,1-9 all of which showed improvement in ESA response, time to maximal response, reduction in ESA dose to reach maximal response, and improvement in quality-oflife parameters (when measured).

CHICAGO—Denosumab delayed or prevented more skeletal-related adverse events than zoledronic acid in men with hormone-refractory prostate cancer and bone metastases.

The superior efficacy of denosumab on this end point along with its ease of administration—subcutaneous rather than intravenous—gives it an edge over zoledronic acid, said Karim Fizazi, MD, PhD, lead investigator of a study comparing the two treatments.

CHICAGO—Twice-daily dosing of naproxen can reduce the incidence and severity of bone pain in cancer patients being treated with pegfilgrastim, according to data presented by New York researchers.

SAN FRANCISCO –An hour-long lecture by a fertility specialist during oncology grand rounds dramatically improves the rate of pretreatment sperm cryopreservation in young men with cancer, according to data presented at the American Urological Association (AUA) 2010 Annual Scientific Meeting.
 
The researchers, from the University of Wisconsin in Madison, found that a single lecture by a urologist specializing in male infertility increased sperm cryopreservation in male cancer patients fourfold.
 
SAN DIEGO—Cancer patients at high risk for bone loss due to their disease or its management may want to cut down on the diet cola consumption. New data presented at the Endocrine Society’s 92nd annual meeting and expo suggest that drinking diet colas on a regular basis may be associated with a decrease in bone mineral density (BMD) and an increased fracture risk.
 
SAN FRANCISCO—Italian researchers have found that delivering a single dose of intravesical chemotherapy preoperatively may be a better approach than postoperative chemotherapy for improving a patient’s risk of recurrence of non–muscle invasive bladder cancer (NMIBC).
 
CHICAGO—A risk stratification schema can be used to identify older patients who are at risk of grade-3 to -5 toxicity from chemotherapy. The schema includes risk factors based on cancer type, patient age, upfront dose of chemotherapy, the chemotherapeutic regimen used, and history of falling, among others, said Arti Hurria, MD at the 46th American Society of Clinical Oncology annual meeting.
 
“We wanted to develop a predictive model for tolerance to therapy in older adults with cancer,” she said.
 
CHICAGO—A fentanyl pectin nasal spray provides analgesia faster than immediate-release morphine in the treatment of breakthrough cancer pain, said Andrew Davies, MD, MSc at the 46th American Society of Clinical Oncology annual meeting.
 
Breakthrough cancer pain is a transient exacerbation of pain that occurs despite relatively stable and adequately controlled background pain and has a significant impact on quality of life.
 
CHICAGO—Twice-daily dosing of naproxen can reduce the incidence and severity of bone pain in cancer patients being treated with pegfilgrastim, according to data presented at the 2010 annual meeting of the American Society of Clinical Oncology.
 
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