Cryoablation Appears Safe and Effective in Low-Risk, Early-Stage Breast Cancer

TOP - July 2021 Vol 14, No 4 - Breast Cancer

Breast cancer cryoablation, which destroys tumor cells by exposing them to subfreezing temperatures, appears to be an effective alternative to surgery for women aged >60 years with low-risk, early-stage breast cancer, according to findings from the ICE3 trial. Interim results from this trial were presented by lead investigator Richard E. Fine, MD, FACS, Breast Surgeon, West Cancer Center & Research Institute, Germantown, TN, during the American Society of Breast Surgeons 22nd Annual Meeting.

In cryoablation, precise tumor engulfment producing an ice ball measuring approximately 3.5 cm to 4 cm that destroys cancerous cells is achieved through a freeze-thaw-freeze treatment cycle using a needle-like nitrogen-chilled probe inserted directly into the tumor with ultrasound guidance. The office-based procedure is routinely used for various types of cancer.

“The noninvasive procedure is fast, painless and can be delivered under local anesthesia in a doctor’s office,” Dr Fine explained.

Study Details

The ICE3 trial, which is the largest controlled liquid nitrogen-based cryoablation trial of early-stage, low-risk breast cancer without subsequent tumor excision, enrolled 194 patients aged >60 years (mean age, 75 years) with tumors measuring ≤1.5 cm. The duration of the cryoablation treatment ranged from 20 to 40 minutes depending on the location and size of the tumor. At the discretion of their treating physician, along with cryoablation, 27 patients received adjuvant radiation, 148 received endocrine therapy, and 1 received chemotherapy. The decision to perform sentinel lymph node biopsy was also left to the discretion of the treating physician.

Follow-up every 6 months from 6 to 60 months included mammography and optional magnetic resonance imaging. The primary end point of the trial was disease recurrence in the ipsilateral breast at 5 years.

At a mean of 34.83 months following treatment, only 2.06% (4 patients) experienced cancer recurrence. Among patients who underwent sentinel lymph node biopsies, 2 of 15 had a positive sentinel node (1 with chronic lymphocytic leukemia and 1 with adenocarcinoma, consistent with primary breast cancer and without recurrence at 60-month follow-up). The 36-month failure-free probability rate was 99.22% (95% confidence interval, 94.58%-99.89%).

Minor adverse events included bruising, localized edema, minor skin freeze burn, rash, minor bleeding from needle insertion, minor local hematoma, skin induration, minor infection, and pruritus. During follow-up visits, 95% of patients and 98% of physicians reported satisfaction with the cosmetic results.

“Recovery time is minimal and cosmetic outcomes are excellent with little loss of breast tissue and no scarring,” Dr Fine said. “Cryoablation potentially represents a dramatic improvement in care for appropriate low-risk patients, and at 3 years posttreatment, the ICE3 trial results are extremely positive,” he added.

Confirming cryoablation as a viable alternative to surgical excision in patients with breast cancer will require further study within a clinical trial or registry, Dr Fine concluded.

Related Items
Tucatinib plus Trastuzumab and Capecitabine Triplet Maintains Survival Benefit in HER2-Positive Metastatic Breast Cancer: Updated Results from HER2CLIMB Trial
Charlie Dawson
TOP - September 2021 Vol 14, No 5 published on September 7, 2021 in Breast Cancer
Pandemic Has Resulted in Later Diagnoses, Worse Outcomes for Patients with Lung Cancer
William Ackerman
TOP - September 2021 Vol 14, No 5 published on September 7, 2021 in COVID-19
Addressing Lung Cancer Screening Disparities in LGBT Populations
William Ackerman
TOP - May 2021 Vol 14, No 3 published on May 14, 2021 in Lung Cancer
Pembrolizumab plus Chemotherapy Improves Progression-Free Survival in Metastatic TNBC
Patricia Stewart
TOP - May 2021 Vol 14, No 3 published on May 14, 2021 in Breast Cancer
Abemaciclib plus Endocrine Therapy Offers Invasive Disease–Free Survival Benefit in Patients with High-Risk, HR-Positive, Early-Stage Breast Cancer
Patricia Stewart
TOP - May 2021 Vol 14, No 3 published on May 14, 2021 in Breast Cancer
Analysis Identifies EGFR as Most Common Mutation in Women with Lung Cancer and No Smoking History
William Ackerman
TOP - May 2021 Vol 14, No 3 published on May 14, 2021 in Lung Cancer
Nivolumab Improves Survival in Patients with Relapsed Malignant Mesothelioma
William Ackerman
TOP - May 2021 Vol 14, No 3 published on May 14, 2021 in Mesothelioma
Breast Cancer Year in Review Introduction
2020 Year in Review - Breast Cancer published on January 24, 2021 in Breast Cancer
Retrospective Analysis Provides Insight into Treatment-Emergent Neutropenia Among Patients with Metastatic Breast Cancer Treated with Ribociclib or Palbociclib
2020 Year in Review - Breast Cancer published on January 24, 2021 in Breast Cancer
Concurrent Use of Medications with Potential Drug–Drug Interactions: Real-World Analysis of Patients Treated with CDK4/6 Inhibitors
2020 Year in Review - Breast Cancer published on January 24, 2021 in Breast Cancer
Last modified: July 22, 2021