ADT Did Not Increase Cardiovascular Mortality Adding androgen-deprivation therapy (ADT) to radiation in men with clinically localized prostate cancer was not associated with increased cardiovascular mortality compared with radiation therapy alone, according to results of a multivariate analysis presented at the annual meeting of the American Society for Radiation Oncology.
Older age (≥70 years), cardiovascular disease, and diabetes mellitus remained strong risk factors for cardiovascular death. To help quell the controversy surrounding the FDA’s request to add safety labeling of risk of cardiovascular disease to gonadotropin-releasing hormone agonists, the researchers analyzed data from a phase 3 trial that included 1979 men with clinically localized stage T1-2 prostate cancer.
The cumulative 10-year incidence of cardiovascular death was 9.8% in the combined ADT and radiation group and 10.7% in the radiation alone arm, which the researchers noted was not statistically significant. Univariate analysis, however, determined that adding ADT improved overall and disease-specific survival but did not worsen cardiovascular mortality.