Supportive Care

SALT LAKE CITY—Although radiation- induced toxicities are common in an outpatient setting, several treatment options have proven very successful—as long as the appropriate monitoring parameters are in place, according to a presentation at the annual meeting of the Hematology/Oncology Pharmacy Association by Makala Pace, PharmD, BCOP, clinical pharmacy specialist at The University of Texas M. D. Anderson Cancer Center in Houston.

SALT LAKE CITY—Although it’s important to strive for no chemotherapy-related medication errors, it’s just as important to have an organized system in place to identify, report, and manage these errors when they occur, according to a presentation at the annual meet ing of the Hematology/Oncology Pharmacy Association.

Use of hormone therapy for menopause is associated with reduced risks for esophageal, gastric, and colorectal cancers, according to results of a prospective study that were then combined with published studies in a meta-analysis. In this British study of women aged 50 to 64 years, researchers found no significant differences in risk by type of hormone therapy, duration of use, or between past and current users. The reduction in risk, however, was small in comparison to the increased risk of breast cancer that has been attributed to hormone therapy in this population.

ANAHEIM—Hypersensitivity or infusion reactions to chemotherapy agents or monoclonal antibodies can be life-threatening but often can be managed with premedications or titration of infusion rates to allow continuance of therapy, said Catherine Christen, PharmD, at the 45th American Society of Health-System Pharmacists Midyear Clinical Meeting & Exposition.

Up to 39% of cancer patient believed they did not receive the physical rehabilitation they needed, and 10% to 24% believed they did not receive other rehabilitation services they required. These are the findings of a group of Danish researchers who used the Oncology Nursing Society definition of “a process by which individuals within their environments are assisted to achieve optimal functioning within limits imposed by cancer,” to survey 2202 cancer patients regarding their perception of the rehabilitation they received.

The evidence backing the use of myeloid growth factors in patients at high risk for febrile neutropenia is solid, according to Jeffrey Crawford, MD, of Duke Cancer Institute, Durham, North Carolina.


Impaired Hydroxylation of 5-Methylcytosine in TET2-Mutated Myeloid Malignancies

Serum Albumin Affects Methotrexate Level Variability and Methotrexate Toxicity

In a multicenter, randomized, phase 2/3 trial, the 4-drug combination oxaliplatin/irinotecan/fluorouracil/leucovorin (FOLFIRINOX) prolonged median overall and progression-free survival and increased the overall response rate compared with gemcitabine, the reference standard, for patients with metastatic pancreatic adenocarcinoma and good performance status (0-1). However, the combination regimen was associated with more adverse events, especially febrile neutropenia, and a decrease in quality of life.


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